Drug interactions
Folic acid + Furosemide
Severity: Minor
Folic acid and Furosemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term loop diuretic use may increase urinary loss of water-soluble vitamins including folate. Clinically important deficiency is uncommon and generally only relevant with poor dietary intake.
What this interaction means in plain words
Folic acid and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Folic acid belongs to Miscellaneous; Furosemide belongs to Cardiovascular.
Why it happens
Increased renal excretion of folate with diuresis; the effect is modest and not well characterized.
What to do
No routine action is needed; ensure adequate dietary folate and check levels if anemia or deficiency is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Folic acid with Furosemide?
MediHelp rates the interaction as minor. Folic acid and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term loop diuretic use may increase urinary loss of water-soluble vitamins including folate. Clinically important deficiency is uncommon and generally only relevant with poor dietary intake.
How serious is the interaction between Folic acid and Furosemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; ensure adequate dietary folate and check levels if anemia or deficiency is suspected.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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