Drug interactions
Fondaparinux + Ketoprofen
Severity: Major
Fondaparinux and Ketoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen taken with fondaparinux raises the likelihood of bleeding, including gastrointestinal and spinal hematoma in neuraxial anesthesia. Fondaparinux labeling advises avoiding agents that affect hemostasis unless essential.
What this interaction means in plain words
Fondaparinux and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fondaparinux belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive effect of selective factor Xa inhibition with NSAID platelet inhibition and gastric mucosal injury.
What to do
Avoid the combination where possible; if required, monitor for bleeding and hemoglobin and review renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Ketoprofen?
MediHelp rates the interaction as major. Fondaparinux and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoprofen taken with fondaparinux raises the likelihood of bleeding, including gastrointestinal and spinal hematoma in neuraxial anesthesia. Fondaparinux labeling advises avoiding agents that affect hemostasis unless essential.
How serious is the interaction between Fondaparinux and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if required, monitor for bleeding and hemoglobin and review renal function.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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