Drug interactions
Fondaparinux + Sertraline
Severity: Moderate
Fondaparinux and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline impairs platelet function, and when taken with the anticoagulant fondaparinux it can raise the likelihood of bruising and clinically significant bleeding, particularly from the gastrointestinal tract. The risk is greatest in older patients and those with other bleeding risk factors.
What this interaction means in plain words
Fondaparinux and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fondaparinux belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
SSRI-induced depletion of platelet serotonin impairs aggregation, adding to the factor Xa inhibition of fondaparinux (pharmacodynamic synergism).
What to do
Monitor for signs of bleeding and check hemoglobin periodically during combined therapy. Consider gastroprotection in patients at high gastrointestinal bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Fondaparinux with Sertraline?
MediHelp rates the interaction as moderate. Fondaparinux and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline impairs platelet function, and when taken with the anticoagulant fondaparinux it can raise the likelihood of bruising and clinically significant bleeding, particularly from the gastrointestinal tract. The risk is greatest in older patients and those with other bleeding risk factors.
How serious is the interaction between Fondaparinux and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check hemoglobin periodically during combined therapy. Consider gastroprotection in patients at high gastrointestinal bleeding risk.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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