Drug interactions
Fondaparinux + Tolfenamic acid
Severity: Major
Fondaparinux and Tolfenamic acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid, an NSAID, inhibits platelet aggregation and can cause gastrointestinal ulceration. With fondaparinux this raises the risk of bleeding.
What this interaction means in plain words
Fondaparinux and Tolfenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fondaparinux belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive impairment of hemostasis from NSAID platelet inhibition and mucosal injury plus factor Xa inhibition.
What to do
Prefer paracetamol or another non-NSAID analgesic. If an NSAID is necessary, use the lowest dose briefly with gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Fondaparinux with Tolfenamic acid?
MediHelp rates the interaction as major. Fondaparinux and Tolfenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tolfenamic acid, an NSAID, inhibits platelet aggregation and can cause gastrointestinal ulceration. With fondaparinux this raises the risk of bleeding.
How serious is the interaction between Fondaparinux and Tolfenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or another non-NSAID analgesic. If an NSAID is necessary, use the lowest dose briefly with gastroprotection and monitor for bleeding.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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