Drug interactions
Fondaparinux + Vitamin e
Severity: Minor
Fondaparinux and Vitamin e: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose vitamin E has weak antiplatelet effects and may slightly increase bleeding tendency with anticoagulants. At ordinary doses a significant effect with fondaparinux is unlikely.
What this interaction means in plain words
Fondaparinux and Vitamin e have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fondaparinux belongs to Cardiovascular; Vitamin e belongs to Gastrointestinal Tract.
Why it happens
High-dose vitamin E may inhibit platelet aggregation, adding to the anticoagulant effect.
What to do
Avoid high-dose vitamin E supplements during fondaparinux therapy. Monitor for bleeding if used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Vitamin e
- Betrixaban + Vitamin e Moderate
- Phenindione + Vitamin e Moderate
- Selumetinib + Vitamin e Moderate
- Vitamin e + Warfarin Moderate
- Alfalfa + Vitamin e Minor
- Antithrombin alfa + Vitamin e Minor
Frequently asked questions
Can I take Fondaparinux with Vitamin e?
MediHelp rates the interaction as minor. Fondaparinux and Vitamin e have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose vitamin E has weak antiplatelet effects and may slightly increase bleeding tendency with anticoagulants. At ordinary doses a significant effect with fondaparinux is unlikely.
How serious is the interaction between Fondaparinux and Vitamin e?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose vitamin E supplements during fondaparinux therapy. Monitor for bleeding if used.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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