Drug interactions
Formoterol + Prochlorperazine
Severity: Moderate
Formoterol and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine can prolong the QT interval, and formoterol may add to this and reduce potassium. The combination may raise arrhythmia risk, particularly with higher doses or electrolyte disturbance.
What this interaction means in plain words
Formoterol and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-agonist related hypokalemia.
What to do
Monitor ECG and potassium in at-risk patients, and use the lowest effective doses. Consider a non-QT-prolonging antiemetic if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Formoterol with Prochlorperazine?
MediHelp rates the interaction as moderate. Formoterol and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine can prolong the QT interval, and formoterol may add to this and reduce potassium. The combination may raise arrhythmia risk, particularly with higher doses or electrolyte disturbance.
How serious is the interaction between Formoterol and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in at-risk patients, and use the lowest effective doses. Consider a non-QT-prolonging antiemetic if QTc is prolonged.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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