Drug interactions
Formoterol-mometasone + Gemifloxacin
Severity: Moderate
Formoterol-mometasone and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin can prolong the QT interval, and formoterol may add to this effect, especially if hypokalemia is present. Fluoroquinolones given with corticosteroids also carry an increased risk of tendinopathy and tendon rupture, though inhaled mometasone has low systemic exposure.
What this interaction means in plain words
Formoterol-mometasone and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation from fluoroquinolone ion channel blockade and beta-2 agonist effects, plus a possible additive tendon toxicity with corticosteroids.
What to do
Obtain an ECG and correct potassium and magnesium in patients with QT risk factors. Counsel patients to stop the fluoroquinolone and report tendon pain promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Gemifloxacin?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin can prolong the QT interval, and formoterol may add to this effect, especially if hypokalemia is present. Fluoroquinolones given with corticosteroids also carry an increased risk of tendinopathy and tendon rupture, though inhaled mometasone has low systemic exposure.
How serious is the interaction between Formoterol-mometasone and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct potassium and magnesium in patients with QT risk factors. Counsel patients to stop the fluoroquinolone and report tendon pain promptly.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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