Drug interactions
Formoterol-mometasone + Gilteritinib
Severity: Moderate
Formoterol-mometasone and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is associated with QTc prolongation and torsades de pointes, and formoterol can also prolong the QT interval and lower potassium. Combined use may increase arrhythmia risk, particularly in patients with electrolyte disturbances.
What this interaction means in plain words
Formoterol-mometasone and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Gilteritinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization, with beta-2 agonist induced hypokalemia.
What to do
Perform ECG monitoring at baseline and during therapy, and correct potassium and magnesium abnormalities. Reduce or hold gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Formoterol-mometasone with Gilteritinib?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib is associated with QTc prolongation and torsades de pointes, and formoterol can also prolong the QT interval and lower potassium. Combined use may increase arrhythmia risk, particularly in patients with electrolyte disturbances.
How serious is the interaction between Formoterol-mometasone and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring at baseline and during therapy, and correct potassium and magnesium abnormalities. Reduce or hold gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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