Drug interactions
Formoterol-mometasone + Iloperidone
Severity: Major
Formoterol-mometasone and Iloperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QTc interval and formoterol can add to this effect and lower potassium. The combination may increase the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Formoterol-mometasone and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization, with beta-2 agonist induced hypokalemia.
What to do
Avoid the combination where possible, or obtain a baseline ECG and monitor QTc and electrolytes. Correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Formoterol-mometasone
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Formoterol-mometasone with Iloperidone?
MediHelp rates the interaction as major. Formoterol-mometasone and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone prolongs the QTc interval and formoterol can add to this effect and lower potassium. The combination may increase the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Formoterol-mometasone and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or obtain a baseline ECG and monitor QTc and electrolytes. Correct potassium and magnesium before and during therapy.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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