Drug interactions
Formoterol-mometasone + Itraconazole
Severity: Moderate
Formoterol-mometasone and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4 and can markedly raise systemic mometasone exposure, leading to Cushingoid effects and adrenal suppression with prolonged use. Itraconazole may also add to QT prolongation with formoterol.
What this interaction means in plain words
Formoterol-mometasone and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Itraconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition reduces mometasone clearance, plus additive QT effects.
What to do
Limit duration of combined use, watch for systemic corticosteroid effects, and consider an alternative corticosteroid such as beclometasone for long-term therapy. Check ECG and electrolytes if QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Itraconazole?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole strongly inhibits CYP3A4 and can markedly raise systemic mometasone exposure, leading to Cushingoid effects and adrenal suppression with prolonged use. Itraconazole may also add to QT prolongation with formoterol.
How serious is the interaction between Formoterol-mometasone and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit duration of combined use, watch for systemic corticosteroid effects, and consider an alternative corticosteroid such as beclometasone for long-term therapy. Check ECG and electrolytes if QT risk factors exist.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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