Drug interactions
Formoterol-mometasone + Labetalol
Severity: Major
Formoterol-mometasone and Labetalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta-receptors and can antagonize the bronchodilator effect of formoterol, and may provoke bronchospasm in asthma or COPD. This can reduce asthma control.
What this interaction means in plain words
Formoterol-mometasone and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Labetalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a nonselective beta-blocker.
What to do
Avoid labetalol in patients with asthma or significant reactive airway disease; choose an alternative antihypertensive such as a calcium channel blocker.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol-mometasone
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Formoterol-mometasone with Labetalol?
MediHelp rates the interaction as major. Formoterol-mometasone and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol blocks beta-receptors and can antagonize the bronchodilator effect of formoterol, and may provoke bronchospasm in asthma or COPD. This can reduce asthma control.
How serious is the interaction between Formoterol-mometasone and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid labetalol in patients with asthma or significant reactive airway disease; choose an alternative antihypertensive such as a calcium channel blocker.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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