Drug interactions
Formoterol-mometasone + Perphenazine
Severity: Moderate
Formoterol-mometasone and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can prolong the QT interval, and formoterol may add to this effect and lower serum potassium. The combination may raise arrhythmia risk, mainly at higher doses or with other predisposing factors.
What this interaction means in plain words
Formoterol-mometasone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation, with beta-2-agonist-induced hypokalemia as a potential contributor.
What to do
Monitor ECG and potassium in patients with cardiac disease or other QT-prolonging drugs. Use the lowest effective doses of both agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Formoterol-mometasone with Perphenazine?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine can prolong the QT interval, and formoterol may add to this effect and lower serum potassium. The combination may raise arrhythmia risk, mainly at higher doses or with other predisposing factors.
How serious is the interaction between Formoterol-mometasone and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in patients with cardiac disease or other QT-prolonging drugs. Use the lowest effective doses of both agents.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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