Drug interactions
Formoterol-mometasone + Ribociclib
Severity: Moderate
Formoterol-mometasone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may raise systemic mometasone exposure, increasing the potential for corticosteroid adverse effects. Ribociclib and formoterol may also both prolong the QT interval. With inhaled mometasone the systemic effect is usually small.
What this interaction means in plain words
Formoterol-mometasone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib reduces mometasone clearance, and both ribociclib and formoterol have additive QT-prolonging effects.
What to do
Monitor ECG and electrolytes, and watch for signs of systemic corticosteroid excess with prolonged use. Consider an alternative inhaled steroid with less CYP3A4 dependence if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Ribociclib?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may raise systemic mometasone exposure, increasing the potential for corticosteroid adverse effects. Ribociclib and formoterol may also both prolong the QT interval. With inhaled mometasone the systemic effect is usually small.
How serious is the interaction between Formoterol-mometasone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for signs of systemic corticosteroid excess with prolonged use. Consider an alternative inhaled steroid with less CYP3A4 dependence if needed.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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