Drug interactions
Fosamprenavir + Posaconazole
Severity: Moderate
Fosamprenavir and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir can lower posaconazole plasma concentrations, which may lead to subtherapeutic antifungal exposure and breakthrough fungal infection.
What this interaction means in plain words
Fosamprenavir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism not firmly established; possible induction of posaconazole elimination pathways such as UGT-mediated glucuronidation or efflux.
What to do
Avoid the combination unless benefit outweighs risk. If used together, monitor posaconazole trough concentrations and watch for breakthrough fungal infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Posaconazole?
MediHelp rates the interaction as moderate. Fosamprenavir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir can lower posaconazole plasma concentrations, which may lead to subtherapeutic antifungal exposure and breakthrough fungal infection.
How serious is the interaction between Fosamprenavir and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless benefit outweighs risk. If used together, monitor posaconazole trough concentrations and watch for breakthrough fungal infection.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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