Drug interactions
Fosaprepitant + Imatinib
Severity: Minor
Fosaprepitant and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor and could modestly raise imatinib levels. With single-dose use the effect is usually small and short-lived.
What this interaction means in plain words
Fosaprepitant and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Imatinib belongs to Oncology.
Why it happens
Aprepitant transiently inhibits CYP3A4-mediated imatinib metabolism.
What to do
No dose change is usually needed for single-dose use. Monitor for imatinib adverse effects if given repeatedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Imatinib?
MediHelp rates the interaction as minor. Fosaprepitant and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor and could modestly raise imatinib levels. With single-dose use the effect is usually small and short-lived.
How serious is the interaction between Fosaprepitant and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for single-dose use. Monitor for imatinib adverse effects if given repeatedly.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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