Drug interactions
Fosaprepitant + Linagliptin-metformin
Severity: Minor
Fosaprepitant and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, a prodrug of aprepitant, is a weak-to-moderate CYP3A4 inhibitor after a single dose. Linagliptin exposure may rise slightly, but this is unlikely to matter clinically given its wide safety margin.
What this interaction means in plain words
Fosaprepitant and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Linagliptin-metformin belongs to Endocrine.
Why it happens
Transient CYP3A4 inhibition by aprepitant slightly reduces linagliptin metabolism.
What to do
No dose adjustment is needed with single-dose use; monitor for linagliptin adverse effects only if exposure is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Linagliptin-metformin?
MediHelp rates the interaction as minor. Fosaprepitant and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, a prodrug of aprepitant, is a weak-to-moderate CYP3A4 inhibitor after a single dose. Linagliptin exposure may rise slightly, but this is unlikely to matter clinically given its wide safety margin.
How serious is the interaction between Fosaprepitant and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed with single-dose use; monitor for linagliptin adverse effects only if exposure is prolonged.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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