Drug interactions
Fosaprepitant + Mifepristone
Severity: Moderate
Fosaprepitant and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, which is metabolized by CYP3A4. Mifepristone may increase aprepitant exposure, although a single fosaprepitant dose has limited duration of effect.
What this interaction means in plain words
Fosaprepitant and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4, decreasing aprepitant clearance.
What to do
Monitor for aprepitant adverse effects such as fatigue, hiccups and hypotension. No routine dose change is needed for a single dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Mifepristone?
MediHelp rates the interaction as moderate. Fosaprepitant and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, which is metabolized by CYP3A4. Mifepristone may increase aprepitant exposure, although a single fosaprepitant dose has limited duration of effect.
How serious is the interaction between Fosaprepitant and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects such as fatigue, hiccups and hypotension. No routine dose change is needed for a single dose.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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