Drug interactions
Fosaprepitant + Nicardipine
Severity: Minor
Fosaprepitant and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor after a single dose and can raise levels of CYP3A4 substrates for several days. Nicardipine exposure may increase modestly, causing hypotension or edema.
What this interaction means in plain words
Fosaprepitant and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Nicardipine belongs to Cardiovascular.
Why it happens
Aprepitant transiently inhibits CYP3A4, decreasing nicardipine metabolism.
What to do
Monitor blood pressure around chemotherapy cycles and reduce the nicardipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Nicardipine?
MediHelp rates the interaction as minor. Fosaprepitant and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor after a single dose and can raise levels of CYP3A4 substrates for several days. Nicardipine exposure may increase modestly, causing hypotension or edema.
How serious is the interaction between Fosaprepitant and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure around chemotherapy cycles and reduce the nicardipine dose if hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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