Drug interactions
Fosaprepitant + Nimodipine
Severity: Minor
Fosaprepitant and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, through aprepitant, is a moderate CYP3A4 inhibitor after single-dose use, which may transiently raise nimodipine concentrations. The effect is usually modest and short-lived.
What this interaction means in plain words
Fosaprepitant and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Nimodipine belongs to Cardiovascular.
Why it happens
Transient CYP3A4 inhibition by aprepitant reduces nimodipine metabolism.
What to do
Monitor blood pressure for a few days after fosaprepitant administration. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Nimodipine?
MediHelp rates the interaction as minor. Fosaprepitant and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, through aprepitant, is a moderate CYP3A4 inhibitor after single-dose use, which may transiently raise nimodipine concentrations. The effect is usually modest and short-lived.
How serious is the interaction between Fosaprepitant and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure for a few days after fosaprepitant administration. No dose change is usually required.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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