Drug interactions
Fosaprepitant + Paclitaxel
Severity: Minor
Fosaprepitant and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant (aprepitant) is a weak-to-moderate CYP3A4 inhibitor and could modestly raise paclitaxel levels. In practice they are routinely given together during chemotherapy without clear clinically relevant toxicity.
What this interaction means in plain words
Fosaprepitant and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Paclitaxel belongs to Oncology.
Why it happens
Aprepitant transiently inhibits CYP3A4, slightly reducing paclitaxel metabolism.
What to do
No dose adjustment is usually required; monitor for neutropenia and neuropathy as per standard paclitaxel care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Paclitaxel?
MediHelp rates the interaction as minor. Fosaprepitant and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant (aprepitant) is a weak-to-moderate CYP3A4 inhibitor and could modestly raise paclitaxel levels. In practice they are routinely given together during chemotherapy without clear clinically relevant toxicity.
How serious is the interaction between Fosaprepitant and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for neutropenia and neuropathy as per standard paclitaxel care.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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