Drug interactions
Fosaprepitant + Prednisone
Severity: Minor
Fosaprepitant and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor and raises exposure to some corticosteroids, notably dexamethasone and methylprednisolone. The effect on prednisone is expected to be smaller because it is not primarily CYP3A4 cleared.
What this interaction means in plain words
Fosaprepitant and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Prednisone belongs to Endocrine.
Why it happens
Aprepitant moderately inhibits CYP3A4, reducing corticosteroid clearance.
What to do
No dose adjustment is generally required for single-dose fosaprepitant; monitor for enhanced steroid effects if used repeatedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Prednisone?
MediHelp rates the interaction as minor. Fosaprepitant and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor and raises exposure to some corticosteroids, notably dexamethasone and methylprednisolone. The effect on prednisone is expected to be smaller because it is not primarily CYP3A4 cleared.
How serious is the interaction between Fosaprepitant and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required for single-dose fosaprepitant; monitor for enhanced steroid effects if used repeatedly.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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