Drug interactions
Fosaprepitant + Propafenone
Severity: Minor
Fosaprepitant and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor, but after a single dose the effect on propafenone is likely small and short-lived. Transient increases in propafenone exposure are possible.
What this interaction means in plain words
Fosaprepitant and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Propafenone belongs to Cardiovascular.
Why it happens
Transient inhibition of CYP3A4-mediated propafenone metabolism.
What to do
No routine dose change is needed with single-dose use. Monitor for palpitations, dizziness or ECG changes after administration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Propafenone?
MediHelp rates the interaction as minor. Fosaprepitant and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor, but after a single dose the effect on propafenone is likely small and short-lived. Transient increases in propafenone exposure are possible.
How serious is the interaction between Fosaprepitant and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed with single-dose use. Monitor for palpitations, dizziness or ECG changes after administration.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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