Drug interactions
Fosaprepitant + Quetiapine
Severity: Minor
Fosaprepitant and Quetiapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may modestly raise quetiapine levels. After a single dose the effect is usually short-lived and small, but sedation and hypotension may be more noticeable.
What this interaction means in plain words
Fosaprepitant and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Quetiapine belongs to Central Nervous System.
Why it happens
Weak to moderate, temporary inhibition of CYP3A4 by aprepitant reduces quetiapine clearance.
What to do
No routine dose change is needed for single-dose use; watch for increased sedation and hypotension for several days after administration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Quetiapine?
MediHelp rates the interaction as minor. Fosaprepitant and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may modestly raise quetiapine levels. After a single dose the effect is usually short-lived and small, but sedation and hypotension may be more noticeable.
How serious is the interaction between Fosaprepitant and Quetiapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for single-dose use; watch for increased sedation and hypotension for several days after administration.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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