Drug interactions
Fosaprepitant + Rifampicin
Severity: Moderate
Fosaprepitant and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin lowers aprepitant exposure after fosaprepitant conversion and may reduce antiemetic efficacy, risking breakthrough nausea and vomiting.
What this interaction means in plain words
Fosaprepitant and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin induces CYP3A4, accelerating aprepitant metabolism.
What to do
Avoid if possible; add or optimize other antiemetics and monitor control of nausea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Fosaprepitant with Rifampicin?
MediHelp rates the interaction as moderate. Fosaprepitant and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin lowers aprepitant exposure after fosaprepitant conversion and may reduce antiemetic efficacy, risking breakthrough nausea and vomiting.
How serious is the interaction between Fosaprepitant and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; add or optimize other antiemetics and monitor control of nausea.
What other medicines interact with Fosaprepitant?
MediHelp also lists interactions of Fosaprepitant with, for example, Flibanserin, Pimozide, Alprazolam. The full list is on the Fosaprepitant page.
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