Drug interactions
Fosaprepitant + Tamsulosin
Severity: Minor
Fosaprepitant and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, through its active metabolite aprepitant, is a moderate CYP3A4 inhibitor. With a single IV dose the effect is transient and tamsulosin exposure may increase modestly, with a small risk of dizziness or hypotension.
What this interaction means in plain words
Fosaprepitant and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Tamsulosin belongs to Genitourinary.
Why it happens
Aprepitant, the active metabolite of fosaprepitant, weakly to moderately inhibits CYP3A4 metabolism of tamsulosin.
What to do
No dose change is normally needed with a single dose. Advise caution on standing and monitor blood pressure if repeated dosing is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Tamsulosin?
MediHelp rates the interaction as minor. Fosaprepitant and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, through its active metabolite aprepitant, is a moderate CYP3A4 inhibitor. With a single IV dose the effect is transient and tamsulosin exposure may increase modestly, with a small risk of dizziness or hypotension.
How serious is the interaction between Fosaprepitant and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed with a single dose. Advise caution on standing and monitor blood pressure if repeated dosing is used.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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