Drug interactions
Fosaprepitant + Vardenafil
Severity: Moderate
Fosaprepitant and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a dose-dependent moderate CYP3A4 inhibitor, which can raise vardenafil exposure after a single IV dose. Higher vardenafil levels may increase hypotension, headache, flushing and QT effects.
What this interaction means in plain words
Fosaprepitant and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Vardenafil belongs to Genitourinary.
Why it happens
Aprepitant, the active metabolite of fosaprepitant, inhibits CYP3A4-mediated metabolism of vardenafil.
What to do
Consider a lower vardenafil dose and monitor blood pressure and symptoms of vasodilation during the days after fosaprepitant. Advise patients to report dizziness or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Vardenafil?
MediHelp rates the interaction as moderate. Fosaprepitant and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a dose-dependent moderate CYP3A4 inhibitor, which can raise vardenafil exposure after a single IV dose. Higher vardenafil levels may increase hypotension, headache, flushing and QT effects.
How serious is the interaction between Fosaprepitant and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower vardenafil dose and monitor blood pressure and symptoms of vasodilation during the days after fosaprepitant. Advise patients to report dizziness or fainting.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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