Drug interactions
Fosaprepitant + Vinblastine
Severity: Moderate
Fosaprepitant and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may modestly increase vinblastine exposure. The effect after a single antiemetic dose is usually small, but toxicity could increase with repeated dosing.
What this interaction means in plain words
Fosaprepitant and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Vinblastine belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing vinblastine metabolism.
What to do
Monitor for neurotoxicity, constipation and myelosuppression, especially with multi-day antiemetic regimens. Adjust vinblastine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Vinblastine?
MediHelp rates the interaction as moderate. Fosaprepitant and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may modestly increase vinblastine exposure. The effect after a single antiemetic dose is usually small, but toxicity could increase with repeated dosing.
How serious is the interaction between Fosaprepitant and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity, constipation and myelosuppression, especially with multi-day antiemetic regimens. Adjust vinblastine dose if toxicity develops.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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