Drug interactions
Foscarnet + Gepirone
Severity: Major
Foscarnet and Gepirone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is an antidepressant with labeled QT prolongation and is contraindicated with other drugs that significantly prolong QT. Foscarnet may prolong QT and cause electrolyte loss, increasing the risk of torsades de pointes.
What this interaction means in plain words
Foscarnet and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Gepirone belongs to Central Nervous System.
Why it happens
Additive QT prolongation with foscarnet-induced electrolyte abnormalities.
What to do
Avoid starting gepirone during foscarnet therapy where possible. If both are needed, monitor ECG and keep electrolytes normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Foscarnet with Gepirone?
MediHelp rates the interaction as major. Foscarnet and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gepirone is an antidepressant with labeled QT prolongation and is contraindicated with other drugs that significantly prolong QT. Foscarnet may prolong QT and cause electrolyte loss, increasing the risk of torsades de pointes.
How serious is the interaction between Foscarnet and Gepirone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting gepirone during foscarnet therapy where possible. If both are needed, monitor ECG and keep electrolytes normal.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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