Drug interactions
Foscarnet + Paromomycin
Severity: Minor
Foscarnet and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is poorly absorbed, so systemic nephrotoxicity is uncommon, but absorption may rise with damaged gut mucosa or renal impairment. Foscarnet is strongly nephrotoxic, so there is a theoretical additive renal risk.
What this interaction means in plain words
Foscarnet and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Foscarnet belongs to Anti Virals; Paromomycin belongs to Anti Bacterial.
Why it happens
Theoretical additive nephrotoxicity if systemic paromomycin exposure occurs.
What to do
Monitor serum creatinine during foscarnet therapy, particularly in patients with bowel inflammation or reduced renal function. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Foscarnet with Paromomycin?
MediHelp rates the interaction as minor. Foscarnet and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is poorly absorbed, so systemic nephrotoxicity is uncommon, but absorption may rise with damaged gut mucosa or renal impairment. Foscarnet is strongly nephrotoxic, so there is a theoretical additive renal risk.
How serious is the interaction between Foscarnet and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine during foscarnet therapy, particularly in patients with bowel inflammation or reduced renal function. No dose change is usually needed.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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