Drug interactions
Foscarnet + Ranolazine
Severity: Moderate
Foscarnet and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine produces dose-related QT prolongation, and foscarnet may add to this and cause electrolyte loss. The combination can raise the risk of ventricular arrhythmia.
What this interaction means in plain words
Foscarnet and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation with electrolyte disturbance.
What to do
Monitor ECG and electrolytes and correct deficits during foscarnet use. Reduce ranolazine dose or stop if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Foscarnet with Ranolazine?
MediHelp rates the interaction as moderate. Foscarnet and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine produces dose-related QT prolongation, and foscarnet may add to this and cause electrolyte loss. The combination can raise the risk of ventricular arrhythmia.
How serious is the interaction between Foscarnet and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and correct deficits during foscarnet use. Reduce ranolazine dose or stop if QTc becomes markedly prolonged.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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