Drug interactions
Fosinopril + Glipizide
Severity: Moderate
Fosinopril and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity, so adding fosinopril to a sulfonylurea may lower blood glucose further. Hypoglycemia can occur, especially when the ACE inhibitor is started or the dose is raised.
What this interaction means in plain words
Fosinopril and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity and glucose uptake, adding to the insulin secretagogue effect of glipizide.
What to do
Monitor blood glucose closely when starting or adjusting fosinopril, particularly in the first weeks. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Glipizide
Frequently asked questions
Can I take Fosinopril with Glipizide?
MediHelp rates the interaction as moderate. Fosinopril and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity, so adding fosinopril to a sulfonylurea may lower blood glucose further. Hypoglycemia can occur, especially when the ACE inhibitor is started or the dose is raised.
How serious is the interaction between Fosinopril and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting fosinopril, particularly in the first weeks. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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