Drug interactions
Fosinopril-hydrochlorothiazide + Gentamicin
Severity: Moderate
Fosinopril-hydrochlorothiazide and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause electrolyte disturbances, and gentamicin can cause renal magnesium and potassium wasting. Diuretics and ACE inhibitors may also add to the risk of aminoglycoside nephrotoxicity in volume-depleted patients.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive renal electrolyte wasting plus hemodynamic and volume-related augmentation of aminoglycoside nephrotoxicity.
What to do
Monitor serum potassium, magnesium and creatinine during gentamicin therapy, and keep patients well hydrated. Consider holding the diuretic and ACE inhibitor if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Gentamicin?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause electrolyte disturbances, and gentamicin can cause renal magnesium and potassium wasting. Diuretics and ACE inhibitors may also add to the risk of aminoglycoside nephrotoxicity in volume-depleted patients.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and creatinine during gentamicin therapy, and keep patients well hydrated. Consider holding the diuretic and ACE inhibitor if renal function deteriorates.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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