Drug interactions
Fosinopril-hydrochlorothiazide + Labetalol
Severity: Moderate
Fosinopril-hydrochlorothiazide and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol and the fosinopril-hydrochlorothiazide combination are both antihypertensives, so blood pressure may fall more than intended, with dizziness or orthostatic hypotension. Potassium effects are small and not a significant concern. The combination is commonly used deliberately when titrated carefully.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from alpha/beta blockade combined with ACE inhibition and diuresis.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting doses. Reduce the dose of one agent if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Labetalol?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol and the fosinopril-hydrochlorothiazide combination are both antihypertensives, so blood pressure may fall more than intended, with dizziness or orthostatic hypotension. Potassium effects are small and not a significant concern. The combination is commonly used deliberately when titrated carefully.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting doses. Reduce the dose of one agent if hypotension occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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