Drug interactions
Fosinopril-hydrochlorothiazide + Liraglutide
Severity: Minor
Fosinopril-hydrochlorothiazide and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and so increase the glucose-lowering effect of antidiabetic drugs. Liraglutide alone rarely causes hypoglycemia, but the risk rises if insulin or a sulfonylurea is also used. Thiazides can in contrast worsen glycemic control slightly.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Possible improved insulin sensitivity from ACE inhibition adds to the glucose-lowering action of liraglutide; the mechanism is not firmly established.
What to do
Monitor blood glucose, particularly in the first weeks of ACE inhibitor therapy. Lower any concurrent sulfonylurea or insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Liraglutide?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may enhance insulin sensitivity and so increase the glucose-lowering effect of antidiabetic drugs. Liraglutide alone rarely causes hypoglycemia, but the risk rises if insulin or a sulfonylurea is also used. Thiazides can in contrast worsen glycemic control slightly.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, particularly in the first weeks of ACE inhibitor therapy. Lower any concurrent sulfonylurea or insulin dose if hypoglycemia occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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