Drug interactions
Fosinopril-hydrochlorothiazide + Lornoxicam
Severity: Moderate
Fosinopril-hydrochlorothiazide and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam blunt the antihypertensive effect of ACE inhibitors and diuretics. Together with these drugs they raise the risk of acute kidney injury, especially in volume-depleted or elderly patients, and may cause hyperkalemia.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium retention and reduced renal perfusion, opposing diuretic and ACE inhibitor effects and impairing glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Lornoxicam?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam blunt the antihypertensive effect of ACE inhibitors and diuretics. Together with these drugs they raise the risk of acute kidney injury, especially in volume-depleted or elderly patients, and may cause hyperkalemia.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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