Drug interactions
Fosinopril-hydrochlorothiazide + Mefenamic acid
Severity: Moderate
Fosinopril-hydrochlorothiazide and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may reduce the antihypertensive effect of fosinopril and hydrochlorothiazide. The combination can impair renal function and cause hyperkalemia in at-risk patients.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, counteracting ACE inhibitor and thiazide effects.
What to do
Prefer a non-NSAID analgesic. If needed, keep to the lowest dose for a short course and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Mefenamic acid?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may reduce the antihypertensive effect of fosinopril and hydrochlorothiazide. The combination can impair renal function and cause hyperkalemia in at-risk patients.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic. If needed, keep to the lowest dose for a short course and monitor blood pressure, creatinine and potassium.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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