Drug interactions
Fosinopril-hydrochlorothiazide + Metoprolol
Severity: Minor
Fosinopril-hydrochlorothiazide and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol is commonly combined with ACE inhibitors and thiazides, but blood pressure and heart rate may fall more than expected. Thiazides can also modestly worsen glucose and lipids, and may mask hypoglycemia symptoms in combination with beta-blockade in diabetics.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through different mechanisms (beta-blockade, ACE inhibition, diuresis).
What to do
Monitor blood pressure and heart rate when starting or titrating, and adjust doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Metoprolol?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoprolol is commonly combined with ACE inhibitors and thiazides, but blood pressure and heart rate may fall more than expected. Thiazides can also modestly worsen glucose and lipids, and may mask hypoglycemia symptoms in combination with beta-blockade in diabetics.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating, and adjust doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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