Drug interactions
Fosinopril-hydrochlorothiazide + Nabumetone
Severity: Moderate
Fosinopril-hydrochlorothiazide and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabumetone may reduce the antihypertensive effect of fosinopril and hydrochlorothiazide and can contribute to renal function decline. Risk is greater in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
Its active metabolite inhibits renal prostaglandin synthesis, reducing renal perfusion and sodium excretion and opposing ACE inhibitor and thiazide effects.
What to do
Prefer a non-NSAID analgesic. If used, choose the lowest effective dose and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Nabumetone?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabumetone may reduce the antihypertensive effect of fosinopril and hydrochlorothiazide and can contribute to renal function decline. Risk is greater in older, volume-depleted or renally impaired patients.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic. If used, choose the lowest effective dose and monitor blood pressure, creatinine and potassium.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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