Drug interactions
Fosinopril-hydrochlorothiazide + Perphenazine
Severity: Minor
Fosinopril-hydrochlorothiazide and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has alpha-blocking and sedative properties that can add to the blood pressure lowering of an ACE inhibitor and thiazide. This may cause orthostatic hypotension, particularly in older patients or at treatment initiation.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from phenothiazine alpha-adrenergic blockade.
What to do
Monitor blood pressure and counsel patients to rise slowly, especially during initiation or dose increases.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Perphenazine?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine has alpha-blocking and sedative properties that can add to the blood pressure lowering of an ACE inhibitor and thiazide. This may cause orthostatic hypotension, particularly in older patients or at treatment initiation.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients to rise slowly, especially during initiation or dose increases.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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