Drug interactions
Fosinopril-hydrochlorothiazide + Saxagliptin
Severity: Minor
Fosinopril-hydrochlorothiazide and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose, particularly at higher doses, which may partly offset the glucose-lowering effect of saxagliptin. At the low doses used in combination products the effect is usually small.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazides cause hyperglycemia through reduced insulin secretion and increased insulin resistance, partly via potassium loss.
What to do
Monitor blood glucose and HbA1c when the thiazide is started or its dose increased. Adjust antidiabetic therapy only if glycemic control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Saxagliptin?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose, particularly at higher doses, which may partly offset the glucose-lowering effect of saxagliptin. At the low doses used in combination products the effect is usually small.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when the thiazide is started or its dose increased. Adjust antidiabetic therapy only if glycemic control worsens.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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