Drug interactions
Fosinopril-hydrochlorothiazide + Sirolimus
Severity: Major
Fosinopril-hydrochlorothiazide and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus combined with an ACE inhibitor has been associated with a higher incidence of angioedema, which can involve the airway. Onset can be delayed.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Both drugs may impair bradykinin degradation (ACE inhibition and mTOR inhibitor effects on DPP-IV), raising bradykinin levels.
What to do
Consider an alternative antihypertensive such as an ARB or calcium channel blocker. If used, counsel patients to seek urgent care for swelling of the face, lips or tongue.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Sirolimus?
MediHelp rates the interaction as major. Fosinopril-hydrochlorothiazide and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sirolimus combined with an ACE inhibitor has been associated with a higher incidence of angioedema, which can involve the airway. Onset can be delayed.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antihypertensive such as an ARB or calcium channel blocker. If used, counsel patients to seek urgent care for swelling of the face, lips or tongue.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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