Drug interactions
Fosinopril-hydrochlorothiazide + Succinylcholine
Severity: Moderate
Fosinopril-hydrochlorothiazide and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine causes a transient rise in serum potassium, which can be harmful when baseline potassium is abnormal. Thiazide-induced hypokalemia may also enhance neuromuscular blockade, and electrolyte disturbances raise arrhythmia risk during anesthesia.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Thiazide-related potassium and electrolyte disturbance alters the neuromuscular and cardiac response to depolarizing blockade.
What to do
Check serum potassium before elective surgery and correct abnormalities. Monitor neuromuscular function and ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Succinylcholine?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine causes a transient rise in serum potassium, which can be harmful when baseline potassium is abnormal. Thiazide-induced hypokalemia may also enhance neuromuscular blockade, and electrolyte disturbances raise arrhythmia risk during anesthesia.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before elective surgery and correct abnormalities. Monitor neuromuscular function and ECG during anesthesia.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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