Drug interactions
Fosinopril-hydrochlorothiazide + Torsemide
Severity: Moderate
Fosinopril-hydrochlorothiazide and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a loop diuretic to an ACE inhibitor and thiazide can cause marked volume depletion, hypotension and acute worsening of renal function. Electrolyte disturbances such as hypokalemia and hyponatremia are also more likely.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Additive diuresis and sodium depletion with activation of the renin system, combined with ACE inhibitor loss of efferent arteriolar tone.
What to do
Monitor blood pressure, renal function and electrolytes after initiation and dose changes. Consider reducing the diuretic dose if volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Torsemide
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Torsemide?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a loop diuretic to an ACE inhibitor and thiazide can cause marked volume depletion, hypotension and acute worsening of renal function. Electrolyte disturbances such as hypokalemia and hyponatremia are also more likely.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after initiation and dose changes. Consider reducing the diuretic dose if volume depleted.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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