Drug interactions
Fosinopril-hydrochlorothiazide + Trientine
Severity: Minor
Fosinopril-hydrochlorothiazide and Trientine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trientine is a copper chelator and diuretics may increase urinary excretion of chelated metals or alter its handling, but no reliable clinical effect on trientine levels is established. The practical significance is uncertain.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Trientine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Trientine belongs to Miscellaneous.
Why it happens
Possible altered renal clearance of trientine; mechanism not well established.
What to do
No routine action needed; monitor urinary copper and clinical response to trientine as part of standard care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril-hydrochlorothiazide and Trientine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Trientine
- Calcium + Trientine Moderate
- Carbonyl iron + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Ferrous sulfate + Trientine Moderate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Trientine?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Trientine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trientine is a copper chelator and diuretics may increase urinary excretion of chelated metals or alter its handling, but no reliable clinical effect on trientine levels is established. The practical significance is uncertain.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Trientine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed; monitor urinary copper and clinical response to trientine as part of standard care.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
