Drug interactions
Fosphenytoin + Secukinumab
Severity: Minor
Fosphenytoin and Secukinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab could reverse inflammatory cytokine suppression of CYP enzymes, altering clearance of phenytoin, the active form of fosphenytoin. Phenytoin has a narrow therapeutic index and nonlinear kinetics. The effect is theoretical.
What this interaction means in plain words
Fosphenytoin and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosphenytoin belongs to Central Nervous System; Secukinumab belongs to Miscellaneous.
Why it happens
Normalization of cytokine-suppressed CYP2C9/2C19 expression after IL-17A blockade, potentially altering phenytoin clearance.
What to do
Check phenytoin concentrations when secukinumab is started or stopped. Adjust the dose based on levels and seizure control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fosphenytoin with Secukinumab?
MediHelp rates the interaction as minor. Fosphenytoin and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secukinumab could reverse inflammatory cytokine suppression of CYP enzymes, altering clearance of phenytoin, the active form of fosphenytoin. Phenytoin has a narrow therapeutic index and nonlinear kinetics. The effect is theoretical.
How serious is the interaction between Fosphenytoin and Secukinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check phenytoin concentrations when secukinumab is started or stopped. Adjust the dose based on levels and seizure control.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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