Drug interactions
Fostamatinib + Ifosfamide
Severity: Minor
Fostamatinib and Ifosfamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite R406 is a weak CYP3A4 inhibitor. Ifosfamide requires CYP3A4 and CYP2B6 activation, but also generates a neurotoxic metabolite through CYP3A4, so any change in exposure is likely small and its clinical direction is uncertain.
What this interaction means in plain words
Fostamatinib and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by R406 may modestly alter ifosfamide bioactivation and metabolite formation.
What to do
No routine change is needed; monitor for ifosfamide efficacy and for neurotoxicity or nephrotoxicity during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Ifosfamide?
MediHelp rates the interaction as minor. Fostamatinib and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite R406 is a weak CYP3A4 inhibitor. Ifosfamide requires CYP3A4 and CYP2B6 activation, but also generates a neurotoxic metabolite through CYP3A4, so any change in exposure is likely small and its clinical direction is uncertain.
How serious is the interaction between Fostamatinib and Ifosfamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for ifosfamide efficacy and for neurotoxicity or nephrotoxicity during treatment.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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