Drug interactions
Fostamatinib + Lidocaine
Severity: Minor
Fostamatinib and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein and may raise exposure to P-gp substrates. Lidocaine is only a modest P-gp substrate, so any increase is likely small, but systemic lidocaine toxicity could be relevant with large doses or in patients with hepatic impairment.
What this interaction means in plain words
Fostamatinib and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Lidocaine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux by tamatinib may modestly increase lidocaine absorption and exposure.
What to do
No routine change is needed for standard lidocaine doses. With high-dose or repeated systemic lidocaine, watch for CNS symptoms such as dizziness, paresthesia or tremor, and for arrhythmia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Lidocaine?
MediHelp rates the interaction as minor. Fostamatinib and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein and may raise exposure to P-gp substrates. Lidocaine is only a modest P-gp substrate, so any increase is likely small, but systemic lidocaine toxicity could be relevant with large doses or in patients with hepatic impairment.
How serious is the interaction between Fostamatinib and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for standard lidocaine doses. With high-dose or repeated systemic lidocaine, watch for CNS symptoms such as dizziness, paresthesia or tremor, and for arrhythmia.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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