Drug interactions
Fostamatinib + Mitoxantrone
Severity: Moderate
Fostamatinib and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits BCRP and can increase exposure to BCRP substrates such as mitoxantrone. This may worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Fostamatinib and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Mitoxantrone belongs to Central Nervous System.
Why it happens
Inhibition of BCRP efflux transport by the active metabolite of fostamatinib reduces mitoxantrone clearance.
What to do
Monitor blood counts and consider reducing the mitoxantrone dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Mitoxantrone?
MediHelp rates the interaction as moderate. Fostamatinib and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite inhibits BCRP and can increase exposure to BCRP substrates such as mitoxantrone. This may worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Fostamatinib and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and consider reducing the mitoxantrone dose if toxicity appears.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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