Drug interactions
Fostamatinib + Morphine
Severity: Minor
Fostamatinib and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein, and morphine is a P-gp substrate. Morphine concentrations and central effects may therefore increase, though the clinical significance is probably small.
What this interaction means in plain words
Fostamatinib and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Morphine belongs to Musculoskeletal.
Why it happens
Inhibition of P-glycoprotein efflux, increasing morphine absorption and CNS exposure.
What to do
Monitor for increased opioid effects such as sedation and respiratory depression, and lower the morphine dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Morphine?
MediHelp rates the interaction as minor. Fostamatinib and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits P-glycoprotein, and morphine is a P-gp substrate. Morphine concentrations and central effects may therefore increase, though the clinical significance is probably small.
How serious is the interaction between Fostamatinib and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased opioid effects such as sedation and respiratory depression, and lower the morphine dose if they appear.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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