Drug interactions
Fostamatinib + Oxcarbazepine
Severity: Moderate
Fostamatinib and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce exposure to R406, the active metabolite of fostamatinib. Strong CYP3A4 inducers lower R406 exposure, and a weaker inducer may do so to a lesser degree. Platelet response could diminish.
What this interaction means in plain words
Fostamatinib and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases metabolism of fostamatinib's active metabolite R406.
What to do
Monitor platelet counts and adjust the fostamatinib dose according to labeling if response falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fostamatinib and Oxcarbazepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Oxcarbazepine?
MediHelp rates the interaction as moderate. Fostamatinib and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce exposure to R406, the active metabolite of fostamatinib. Strong CYP3A4 inducers lower R406 exposure, and a weaker inducer may do so to a lesser degree. Platelet response could diminish.
How serious is the interaction between Fostamatinib and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and adjust the fostamatinib dose according to labeling if response falls.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
